SCIENCE

Summary of Research

Shin-Ichi FUKUOKA started his career to be a scientist in biological science and had education at Kyoto University in Japan (BA,MA and Ph.D), Rockefeller University and Harvard Medical School (postdoc). His research field has been exocrine pancreas, secretory pathway, membrane-anchored proteins, tryptophan metabolism in the brain and mad cow disease (BSE). He is doing a theoretical modeling of the dynamic equilibrium which makes life alive. He has run laboratories and taught at Kyoto University and Aoyama Gakuin University (Tokyo).

His research team has published papers in prestigious scientific journals including Nature, JBC, PNAS and Pros One. He is now a visiting professor at Rockefeller University (NYC) to continue the research. The whole list of publications are shown in below.

Authors：Arii Y, Yamaguchi H, Yamasaki M, Fukuoka S.　

Title：Detection of an interaction between prion protein and neuregulin I-β1 by fluorescence resonance energy transfer analysis.　

Journal ：Biosci Biotechnol Biochem. 　

Vol ：Jan 21　

Pages：1-8

(Epub ahead of print)　

Year：2016　

Authors：Matsumura T, Sugawara Y, Yutani M, Amatsu S, Yagita H, Kohda T, Fukuoka S, Nakamura Y, Fukuda S, Hase K, Ohno H, Fujinaga Y.　

Title：Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity.　

Journal ：Nat Commun. 　

Vol ：17-Feb　

Pages：6:6255　

Year：2015　

Authors：Arii Y, Butsusihta K, Fukuoka S.　

Title：Role of calcium-binding sites in calcium-dependent membrane association of annexin A4.　

Journal ：Biosci Biotechnol Biochem. 　

Vol ：79(6)　

Pages：978-85　

Year：2015　

Authors：Shima H, Watanabe T, Fukuda S, Fukuoka S, Ohara O, Ohno H.　

Title：A novel mucosal vaccine targeting Peyer's patch M cells induces protective antigen-specific IgA responses.　

Journal ：Int Immunol. 　

Vol ：Nov;26(11)　

Pages：619-25　

Year：2014　

Authors：Youn HS, Kim MK, Kang GB, Kim TG, Lee JG, An JY, Park KR, Lee Y, Kang JY, Song HE, Park I, Cho C, Fukuoka S, Eom SH.　

Title：Crystal structure of Sus scrofa quinolinate phosphoribosyltransferase in complex with nicotinate mononucleotide.　

Journal ：PLoS One.　

Vol ：23-Apr　

Pages：8(4):e62027　

Year：2013　

Authors：Terakata M, Fukuwatari T, Sano M, Nakao N, Sasaki R, Fukuoka S, Shibata K.　

Title：Establishment of true niacin deficiency in quinolinic acid phosphoribosyltransferase knockout mice.　

Journal ：J Nutr. 　

Vol ：142(12)　

Pages：2148-53　

Year：2012　

Authors：Kang GB, Kim MK, Youn HS, An JY, Lee JG, Park KR, Lee SH, Kim Y, Fukuoka S, Eom SH.　

Title：Crystallization and preliminary X-ray crystallographic analysis of human quinolinate phosphoribosyltransferase.　

Journal ：Acta Crystallogr Sect F Struct Biol Cryst Commun. 　

Vol ：Jan 1　

Pages：67(Pt 1):38-40.　

Year：2011　

Authors：Arii Y, Oshiro S, Wada K, Fukuoka S.　

Title：Production of a recombinant full-length prion protein in a soluble form without refolding or detergents.　

Journal ：Biosci Biotechnol Biochem.　

Vol ：75(6)　

Pages：1181-3　

Year：2011　

Authors：Takei S, Tokuhira Y, Shimada A, Hosokawa M, Fukuoka S.　

Title：The eosin-shadow method: a selective enhancement of light-microscopic visualization of pancreatic zymogen granules on hematoxylin-eosin sections.　

Journal ：Anat Sci Int.　

Vol ：25-Dec　

Year：2009　

Authors：Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K,Tobe T, Fujimura Y, Kawano S, Yabashi A, Waguri S, Nakato G, Kimura S, Murakami T, Iimura M, Hamura K, Fukuoka S, Lowe AW, Itoh K, Kiyono H, Ohno H.　

Title：Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.　

Journal ：Nature.　

Vol ：12-Nov　

Pages：462(7270) :226-30　

Year：2009　

Authors：Butsushita K, Fukuoka S, Ida K, Arii Y.　

Title：Crystal structures of sodium-bound annexin A4.　

Journal ：Biosci Biotechnol Biochem.　

Vol ：Oct;73(10)　

Pages：2274-80　

Year：2009　

Authors：Arii Y, Yamaguchi H, Fukuoka S.　

Title：Production of a soluble recombinant prion protein fused to blue fluorescent protein without refolding or detergents in Escherichia coli cells.　

Journal ：Biosci Biotechnol Biochem.　

Vol ：Oct;71 (10)　

Year：2007　